Yes — Daxxify received FDA approval in 2022 and has been used extensively since. It uses a novel peptide excipient instead of human serum albumin, which is a meaningful formulation difference from all other currently approved toxins. It has a well-established safety profile in clinical trials and post-market use.

How much does Daxxify cost?

At RELUXE, Daxxify is $280 for your first 40 units, then $5.75/unit ($5 at member pricing, which new patients get on their first visit). A most-popular full upper face is about 100 units, roughly $625. Your provider confirms your exact dose at a free consultation. Compare the per-visit total with Botox, then the yearly total — the extended duration may make the annual cost lower.

Can I switch from Botox to Daxxify?

Yes, but we recommend switching after at least one treatment cycle to establish your dosing baseline. Your provider will adjust units appropriately. Daxxify uses different unit measurement than Botox — direct unit-for-unit comparison isn't straightforward.

Will I look frozen with Daxxify?

No more than with Botox at the same dose and provider skill level. Daxxify results look natural when dosed appropriately. Because it may last longer, starting conservatively on a first treatment is wise — your provider can add more at a follow-up if desired.

Which toxin should I get — Botox, Jeuveau, Dysport, or Daxxify?

At RELUXE, we carry all four and help you choose based on your anatomy, history, goals, and how often you want to maintain. Botox and Jeuveau are the most similar in onset/duration. Dysport spreads slightly broader and works well for large areas. Daxxify is the best candidate if you want fewer annual visits and have a stable dosing history.

Is there a consultation fee?

No — all consultations at RELUXE are free. Your provider will map your expressions, discuss your history with tox, and help you choose the right product for your goals.

Treatment Comparison

Botox vs. Daxxify

Daxxify is one of the newer FDA-approved neurotoxins and the only one formulated without human serum albumin. But is it better than Botox — or just different? Here's an honest breakdown.

Last updated October 14, 2026

View Neurotoxins (Wrinkle Relaxers)

The Bottom Line

Botox and Daxxify are both FDA-approved neurotoxins that temporarily relax muscles to smooth expression lines — forehead, frown lines, and crow's feet. They're both injected in-office with no downtime, and both produce natural-looking results in expert hands.

Want help choosing? Book a free consult at either RELUXE location:

Carmel, IN Westfield, IN

See our locations: RELUXE Med Spa in Westfield, IN and RELUXE Med Spa in Carmel, IN.

The key difference is duration and formulation. Daxxify (prabotulinumtoxinA-xvfs) uses a novel peptide exchange technology without human serum albumin, and clinical trials show it may last 4–6 months versus the typical 3–4 months for Botox. At RELUXE, we carry both — and help every patient understand whether the longer duration justifies the price difference for their goals.

Side-by-Side

Botox® vs. Daxxify®

	Botox®	Daxxify®
Active Ingredient	OnabotulinumtoxinA	DaxibotulinumtoxinA-lanm
FDA Approved Since	2002 (cosmetic)	2022
Formulation	Human serum albumin	Peptide excipient (albumin-free)
Onset	3–7 days	2–4 days
Full Results	~14 days	~14 days
Duration (typical)	3–4 months	4–6 months (varies)
Fewer Injections/Year	~3–4 visits/year	~2–3 visits/year
Unit Pricing	$280 for 20 units, then $11/unit	$280 for 40 units, then $5.75/unit
Loyalty Rewards	Allē Rewards (Allergan)	Revance Rewards
Availability at RELUXE	Both locations	Both locations

* Daxxify duration varies by patient — some see 6 months, others see 4. Clinical results are patient-specific.

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Quick Pick

Best for…

Pick Botox® if you prioritize:

Formulation
Onset
Duration (typical)
Fewer Injections/Year

Learn more about Botox®

Pick Daxxify® if you prioritize:

See the full comparison above — your provider helps you choose.

Learn more about Daxxify®

Not sure? Book a free consult — your RELUXE provider helps you decide based on your anatomy, goals, and budget.

Members Save More

Preferred pricing on every visit

Members get member per-unit pricing on tox, $50 off every syringe of filler, a member price on every service (never less than 10% off), and 15% off products.

Learn About Membership →

What Makes Botox Unique

Botox has the longest safety record in aesthetics — over 20 years of clinical use, billions of treatments, and well-documented outcomes. If you've had consistent, predictable results with Botox and are happy with quarterly maintenance visits, there's no compelling reason to switch. Botox is also the standard for medical uses like hyperhidrosis and migraine — if you're using it therapeutically, switching to Daxxify isn't appropriate for those indications.

What Makes Daxxify Unique

Daxxify is a strong option for patients who want to reduce the frequency of maintenance visits. If you find yourself booking Botox every 3 months and want to stretch that to every 5–6 months, Daxxify may deliver that — for some patients. Its albumin-free peptide formulation also appeals to patients who prefer to avoid animal-derived ingredients in their injectables. RELUXE recommends discussing it with your injector if you've had Botox for at least one prior treatment and have a stable dosing history.

A Note on Duration Claims

Daxxify's clinical trials showed median duration of approximately 6 months — significantly longer than Botox or other toxins. However, real-world results vary. Some patients see 5–6 months; others see 4. Individual metabolism, treatment area, muscle strength, and dose all affect how long any neurotoxin lasts. At RELUXE, we set realistic expectations: Daxxify often lasts longer, but results are patient-specific.

What About Cost Per Year?

Compare the yearly total, not just the visit — if Daxxify extends your interval from 3 months to 5–6, your total annual cost may be similar or lower. For example, at standard pricing a full upper face is about $764 with Botox (~64 units) and about $625 with Daxxify (~100 units). Three Botox visits a year is about $2,292; if Daxxify stretches your interval so you need two, that is about $1,250. Results vary by individual. Your provider can walk through the math based on your specific area, dose, and goals. The right answer depends on how your body responds.

FAQs

Botox vs. Daxxify Questions

For many patients, yes — clinical trials showed median duration of ~6 months vs. ~3–4 months for Botox. However, real-world results vary. Some patients see 5–6 months, others see 4. Your individual metabolism, treatment area, and dose affect duration. We recommend trying it after you have a stable Botox dosing history as a baseline.

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The 100-Day Tox Cycle

This content is for educational purposes only and does not constitute medical advice, diagnosis, or treatment recommendations. Individual results vary. A consultation with your provider is required before any treatment to determine the best plan for your specific needs and medical history.

Find Your Ideal Neurotoxin

Book a free consultation at RELUXE Med Spa in Carmel or Westfield. We carry Botox, Jeuveau, Dysport, and Daxxify — your injector will recommend the right product for your face, goals, and schedule.

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